The fidelity of cellular processes that control and execute the biosynthesis of mRNA and proteins declines with age and when challenged by external stressors. This decline results in the production of physiologically unfavorable quantities (amounts) and poor quality (e.g. erroneous sequence, altered folding, or localization) of mRNA and proteins. We and others have shown that this fidelity decline contributes to disease mechanisms and to age-associated physiological changes. Whereas some of the processes involved in either mRNA or protein biosynthesis have been studied at great detail, an integrated, comprehensive view of the systemic consequences of fidelity decline is lacking. This Collaborative Research Centre (CRC) aims to address how fidelity changes in mRNA and protein biosynthesis collectively impact cellular and organismal functions.
Institute of Molecular Biology, Johannes Gutenberg University, Mainz
Institute for Genetics, CECAD, University of Cologne
Center for Molecular Medicine Cologne, University of Cologne
Institute for Genetics, University of Cologne
Center for Molecular Medicine Cologne, University of Cologne
Institute for Genetics, CECAD, University of Cologne
Max Planck Institute for Biology of Ageing, Cologne
Institute for Biochemistry and Molecular Biology, University of Hamburg
Institute for Genetics, CECAD, University of Cologne
Max Planck Institute for Molecular Genetics, Berlin
Department II of Internal Medicine, University of Cologne
Max Planck Institute for Biology of Ageing, Cologne
Institute of Pathology, University Medical Center Göttingen
Institute of Molecular Systems Biology, ETH Zürich
Institute for Biochemistry, University of Cologne
Institute for Genome Stability and Aging, CECAD, University of Cologne
Institute of Medical Statistics and Computational Biology, University of Cologne
Institute for Biochemistry, University of Cologne
CECAD, University of Cologne
Institute for Biochemistry, University of Cologne